Description

1-m-Tolyl-1-Tosylmethyl Isocyanide is a specialized organic building block featuring a unique isocyanide functional group. This compound is valued for its role as a versatile intermediate in multi-component reactions and heterocyclic synthesis, enabling the construction of complex molecular architectures. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for libraries of nitrogen-containing heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides through structure-activity relationship (SAR) studies.
• Material Science: Serves as a building block for functional polymers and advanced organic materials with tailored properties.
• Academic & Discovery Chemistry: Employed in multi-component reactions (MCRs) like the Ugi and Passerini reactions for rapid generation of chemical diversity.
• Chemical Biology: Utilized as a probe or tag in bioconjugation chemistry due to the reactivity of the isocyanide group.

Basic Information

Product Name	1-m-Tolyl-1-Tosylmethyl Isocyanide
CAS No.	459216-21-8
Molecular Formula	C16H15NO2S
Molecular Weight	285.36 g/mol
Synonyms	1-(m-Tolyl)-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; 1-(3-Methylphenyl)-1-[(4-methylphenyl)sulfonyl]methyl isocyanide; 1-m-Tolyl-1-(p-tolylsulfonyl)methyl isocyanide; 1-(3-Methylphenyl)-1-(tosylmethyl) isocyanide; TosMIC m-tolyl derivative; Isocyanide, [[(4-methylphenyl)sulfonyl](3-methylphenyl)methyl]-; [[(4-Methylphenyl)sulfonyl](3-methylphenyl)methyl] isocyanide
EINECS	Contact for details

Quality Control

Our 1-m-Tolyl-1-Tosylmethyl Isocyanide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is analyzed using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.