Description

4-Piperidineaceticacid,5-Ethyl-2-Oxo-,Ethylester,(4R,5S)-(9Ci) is a high-purity, stereochemically defined piperidine derivative used as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) where specific stereochemistry is essential for biological activity. Pharmaceutical research and fine chemical synthesis laboratories need this precise intermediate to ensure the efficacy and regulatory compliance of their final drug candidates and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and other bioactive molecules.
• Asymmetric Synthesis: Employed as a sophisticated building block in stereoselective synthesis to introduce the (4R,5S) configuration into target molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for API manufacturing under GMP conditions.
• Fine Chemical Production: Utilized in the custom synthesis of complex, high-value specialty chemicals for agrochemical and material science applications.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and catalysis research.

Basic Information

Product Name	4-Piperidineaceticacid,5-Ethyl-2-Oxo-,Ethylester,(4R,5S)-(9Ci)
CAS No.	457623-01-7
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(4R,5S)-5-Ethyl-2-oxo-4-piperidineacetic acid ethyl ester; Ethyl (4R,5S)-5-ethyl-2-oxopiperidine-4-acetate; 4-Piperidineacetic acid, 5-ethyl-2-oxo-, ethyl ester, (4R,5S)-; (4R,5S)-5-Ethyl-2-oxo-4-piperidinylacetic acid ethyl ester; (4R,5S)-Ethyl 5-ethyl-2-oxopiperidine-4-carboxylate (common misnomer); 457623-01-7; (4R-cis)-5-Ethyl-2-oxo-4-piperidineacetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced intermediates. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are provided, detailing specifications such as enantiomeric excess (ee), chemical purity by HPLC, and residual solvent content. We support development and cGMP manufacturing with traceable documentation and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is compatible with strong alkali/organic solvents but should be kept under an inert atmosphere if long-term storage is required to minimize potential degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.