Description

3-Pyridinecarbonitrile, 1,2-Dihydro-6-Hydroxy-1,4-Bis(1-Methylethyl)-2-Oxo- (9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research and development pipelines. It is primarily sought by pharmaceutical manufacturers and contract research organizations (CROs) engaged in developing new therapeutic agents, where precise chemical structure and purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug molecules, especially in oncology and central nervous system (CNS) therapeutic areas.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final chemical structure of target APIs, contributing specific functional groups necessary for biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of clinical trial materials.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in analytical laboratories.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents and pesticides.

Basic Information

Product Name	3-Pyridinecarbonitrile, 1,2-Dihydro-6-Hydroxy-1,4-Bis(1-Methylethyl)-2-Oxo- (9Ci)
CAS No.	457604-62-5
Molecular Formula	C14H18N2O2
Molecular Weight	246.31 g/mol
Synonyms	1,2-Dihydro-6-hydroxy-1,4-diisopropyl-2-oxo-3-pyridinecarbonitrile; 6-Hydroxy-1,4-diisopropyl-2-oxo-1,2-dihydropyridine-3-carbonitrile; 3-Cyano-6-hydroxy-1,4-diisopropyl-2(1H)-pyridinone; 1,4-Diisopropyl-6-hydroxy-2-oxo-1,2-dihydropyridine-3-carbonitrile; CAS 457604-62-5
EINECS	Contact for details

Quality Control

Our production of 3-Pyridinecarbonitrile, 1,2-Dihydro-6-Hydroxy-1,4-Bis(1-Methylethyl)-2-Oxo- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.