Description

1-Piperidinecarboxylic Acid, 3-Amino-4-Hydroxy-, 1,1-Dimethylethyl Ester is a high-value, protected amino acid derivative featuring a piperidine backbone with both amino and hydroxy functional groups. This compound matters as a critical chiral building block and intermediate in modern pharmaceutical synthesis, enabling the development of complex, biologically active molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the production of active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for constructing peptide-like structures with enhanced metabolic stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal complexation.
• Agrochemical Research: Employed as a building block for developing new crop protection agents and herbicides.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring a protected, multifunctional piperidine scaffold.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-Amino-4-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	454709-92-3
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl 3-amino-4-hydroxypiperidine-1-carboxylate; 3-Amino-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; Boc-3-amino-4-hydroxypiperidine; 1-Boc-3-amino-4-hydroxypiperidine; 3-Amino-4-hydroxy-1-N-Boc-piperidine; 1-(tert-Butoxycarbonyl)-3-amino-4-hydroxypiperidine; 4-Hydroxy-3-aminopiperidine-1-carboxylic acid tert-butyl ester; 3-Amino-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 3-Amino-4-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are provided for every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.