Description

4-(5-Ethynyl-2-Pyridinyl)Morpholine is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture combining a pyridine ring, an ethynyl group, and a morpholine moiety. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology and kinase inhibitor research. It is primarily required by R&D laboratories, process development chemists, and large-scale manufacturers within the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Serves as a defined starting material for developing robust, scalable manufacturing routes for Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Probe Development: The reactive ethynyl group enables click chemistry applications for creating diagnostic probes or antibody-drug conjugates (ADCs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional labs for studying novel heterocyclic compounds and their biological activities.

Basic Information

Product Name	4-(5-Ethynyl-2-Pyridinyl)Morpholine
CAS No.	454685-29-1
Molecular Formula	C11H12N2O
Molecular Weight	188.23 g/mol
Synonyms	4-(5-Ethynylpyridin-2-yl)morpholine; 2-(Morpholin-4-yl)-5-ethynylpyridine; 5-Ethynyl-2-morpholinopyridine; 4-(5-Ethynyl-2-pyridyl)morpholine; Morpholine, 4-(5-ethynyl-2-pyridinyl)-; 454685-29-1 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 4-(5-Ethynyl-2-Pyridinyl)Morpholine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D. Our quality commitment includes comprehensive characterization by HPLC, GC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its easily oxidized nature, prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.