Description

5-Bromo-2-(2,4-difluorophenyl)pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the bioactivity of the difluorophenylpyridine scaffold.
• Material Science Research: Serves as a monomer or functional unit in the creation of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	5-Bromo-2-(2,4-difluorophenyl)pyridine
CAS No.	453530-70-6
Molecular Formula	C11H6BrF2N
Molecular Weight	270.07 g/mol
Synonyms	2-(2,4-Difluorophenyl)-5-bromopyridine; 5-Bromo-2-(2,4-difluorophenyl)pyridine; 5-Bromo-2-(2,4-difluorophenyl)pyridine; 453530-70-6; 2,4-Difluoro-5-bromophenylpyridine; Pyridine, 5-bromo-2-(2,4-difluorophenyl)-; 5-Bromo-2-(2,4-difluorophenyl)pyridine (CAS 453530-70-6)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for identity confirmation. Certificates of Analysis (COA) are available upon request for every batch, detailing all relevant specifications. Our quality management system is designed to meet the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.