Description

(3R,4S)-4-Ethyl-8-Methoxy-6-Trimethylsilanyl-3,4-Dihydro-1H-Pyrano[3,4-C]Pyridine-3,4-Diol is a high-purity, advanced pharmaceutical intermediate characterized by its unique chiral pyranopyridine core structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, functionalized heterocyclic scaffold.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Exploited as a chiral synthon or auxiliary in stereoselective chemical transformations.
• Reference Standard: Used as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Academic & Industrial R&D: Fundamental research tool for exploring new chemical space and developing novel synthetic methodologies.

Basic Information

Product Name	(3R,4S)-4-Ethyl-8-Methoxy-6-Trimethylsilanyl-3,4-Dihydro-1H-Pyrano[3,4-C]Pyridine-3,4-Diol
CAS No.	453518-24-6
Molecular Formula	C16H27NO4Si
Molecular Weight	325.48 g/mol
Synonyms	4-Ethyl-8-methoxy-6-(trimethylsilyl)-3,4-dihydro-1H-pyrano[3,4-c]pyridine-3,4-diol; (3R,4S)-4-Ethyl-8-methoxy-6-(trimethylsilyl)-3,4-dihydro-1H,5H-pyrano[3,4-c]pyridine-3,4-diol; 6-(Trimethylsilyl)-4-ethyl-8-methoxy-3,4-dihydro-1H-pyrano[3,4-c]pyridine-3,4-diol; TMS-Pyranopyridine Diol Derivative; CAS 453518-24-6
EINECS	Contact for details

Quality Control

Our (3R,4S)-4-Ethyl-8-Methoxy-6-Trimethylsilanyl-3,4-Dihydro-1H-Pyrano[3,4-C]Pyridine-3,4-Diol is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic characterization (NMR, MS) are provided to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.