Description

3-Bromo-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. This compound matters because it combines a reactive halogen handle with a protected boronic ester, enabling sequential cross-coupling reactions to construct complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and advanced functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to construct pyridine-based herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel bidentate and tridentate ligands used in homogeneous catalysis.
• Materials Science Research: Employed in the synthesis of organic semiconductors, metal-organic frameworks (MOFs), and liquid crystals due to its rigid, planar structure.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for studying biological pathways and protein interactions.
• Sequential Functionalization: Enables precise, step-wise construction of complex, multi-substituted aromatic systems in medicinal chemistry programs.

Basic Information

Item	Details
Product Name	3-Bromo-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine
CAS No.	452972-13-3
Molecular Formula	C11H15BBrNO2
Molecular Weight	284.96 g/mol
Synonyms	3-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Bromo-3-pyridineboronic acid pinacol ester; (5-Bromopyridin-3-yl)boronic acid pinacol ester; 3-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 452972-13-3; 3-Bromo-5-pyridylboronic acid pinacol ester; Pinacol (5-bromopyridin-3-yl)boronate
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical specifications are provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.