Description

Methyl 4-(4-(3-(Pyridin-2-Yl)-1-Trityl-1H-Pyrazol-4-Yl)Pyridin-2-Yl)Benzoate CAS NO 452343-16-7 is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure with multiple aromatic and pyrazole rings. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and development of new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug molecules, especially those targeting kinase inhibition or other protein-protein interactions.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) in academic and industrial labs.
• API Synthesis: Integral in the production route for potential APIs in oncology, anti-inflammatory, and central nervous system (CNS) therapeutic categories.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation due to its specific binding motifs.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of bespoke compounds for client-specific drug discovery programs.
• Process Chemistry Optimization: Acts as a standard or intermediate in scaling up and optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	Methyl 4-(4-(3-(Pyridin-2-Yl)-1-Trityl-1H-Pyrazol-4-Yl)Pyridin-2-Yl)Benzoate
CAS No.	452343-16-7
Molecular Formula	C41H30N4O2
Molecular Weight	610.71 g/mol
Synonyms	Methyl 4-[4-[3-(2-Pyridinyl)-1-(triphenylmethyl)-1H-pyrazol-4-yl]-2-pyridinyl]benzoate; 452343-16-7; 4'-(3-(Pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-[2,4'-bipyridine]-5-carboxylic acid methyl ester; 1-Trityl-4-[4-(4-methoxycarbonylphenyl)pyridin-2-yl]-3-(pyridin-2-yl)pyrazole; Methyl 4-(4-{3-(pyridin-2-yl)-1-[(triphenylmethyl)]-1H-pyrazol-4-yl}pyridin-2-yl)benzoate
EINECS	Contact for details

Quality Control

Our Methyl 4-(4-(3-(Pyridin-2-Yl)-1-Trityl-1H-Pyrazol-4-Yl)Pyridin-2-Yl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.