Description

1-(3-Fluorobenzyl)Piperidine-4-Carboxylic Acid Hydrochloride is a high-purity, synthetically versatile organic building block, primarily valued for its role as a key intermediate in pharmaceutical research and development. Its molecular structure, featuring both a fluorinated benzyl group and a piperidine carboxylic acid core, makes it a critical precursor for constructing complex molecules with potential biological activity. This compound is essential for medicinal chemists and process development scientists working in drug discovery, particularly for central nervous system (CNS) and other therapeutic targets.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Process Chemistry & Scale-up: Serves as a defined starting material for developing robust and scalable synthetic routes to target molecules under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying biological pathways and target validation.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) in early-stage drug discovery.

Basic Information

Product Name	1-(3-Fluorobenzyl)Piperidine-4-Carboxylic Acid Hydrochloride
CAS No.	451485-55-5
Molecular Formula	C14H18FNO2·HCl
Molecular Weight	287.76 g/mol (Free base: 251.30 g/mol)
Synonyms	4-Piperidinecarboxylic acid, 1-[(3-fluorophenyl)methyl]-, hydrochloride (1:1); 1-[(3-Fluorophenyl)methyl]piperidine-4-carboxylic acid hydrochloride; 1-(3-Fluorobenzyl)isonipecotic acid hydrochloride; 3-Fluorobenzyl isonipecotate hydrochloride; 1-(3-Fluorobenzyl)-4-piperidinecarboxylic acid HCl; 451485-55-5; 1-(3-Fluorobenzyl)piperidine-4-carboxylic acid HCl salt
EINECS	Contact for details

Quality Control

Our 1-(3-Fluorobenzyl)Piperidine-4-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.