Description

2-Bromo-6-Methyl-4-Trifluoromethylpyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoromethyl and bromo substituents make it an exceptionally versatile intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures.
• Chemical Biology & Proteomics: Employed as a molecular tag or linker in the design of chemical probes for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Bromo-6-Methyl-4-Trifluoromethylpyridine
CAS No.	451459-17-9
Molecular Formula	C8H5BrF3N
Molecular Weight	240.03 g/mol
Synonyms	4-(Trifluoromethyl)-2-bromo-6-methylpyridine; 2-Bromo-6-methyl-4-(trifluoromethyl)pyridine; 6-Methyl-2-bromo-4-trifluoromethylpyridine; Pyridine, 2-bromo-6-methyl-4-(trifluoromethyl)-; 451459-17-9; 2-Bromo-6-methyl-α,α,α-trifluoro-p-toluidine (related); 2-Bromo-4-trifluoromethyl-6-picoline
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-6-Methyl-4-Trifluoromethylpyridine is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.