Description

3-Chloromethyl-2-Fluoro-4-Methoxypyridine is a versatile and high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring reactive chloromethyl and methoxy substituents on a fluoropyridine core, makes it an indispensable intermediate for constructing complex pharmacophores. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients. Its precise functionalization enables the synthesis of targeted molecules with enhanced biological activity and specificity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom can improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of novel organic electronic materials, liquid crystals, and functional polymers.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental component for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	3-Chloromethyl-2-Fluoro-4-Methoxypyridine
CAS No.	451459-10-2
Molecular Formula	C7H7ClFNO
Molecular Weight	175.59 g/mol
Synonyms	2-Fluoro-4-methoxy-3-(chloromethyl)pyridine; 3-(Chloromethyl)-2-fluoro-4-methoxypyridine; 2-Fluoro-3-chloromethyl-4-methoxypyridine; 4-Methoxy-2-fluoro-3-pyridinemethanol, chloromethyl ether; Pyridine, 3-(chloromethyl)-2-fluoro-4-methoxy-; (2-Fluoro-4-methoxypyridin-3-yl)methyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Chloromethyl-2-Fluoro-4-Methoxypyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles. Our quality protocols are designed to support regulatory filings and ensure supply chain reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.