Description

4-Pyridinecarboxamide,n-[(2R)-1,2,3,4-Tetrahydro-2-Naphthalenyl]-(9Ci) CAS NO 449181-60-6 is a high-purity chiral organic compound featuring a pyridinecarboxamide core linked to a tetralin moiety. This specific stereochemistry and molecular architecture make it a critical intermediate in advanced pharmaceutical research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereochemistry and functional groups.
• Asymmetric Synthesis: Serves as a precursor or reagent in catalytic asymmetric reactions to create complex, enantiomerically pure molecules.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and advanced materials requiring high stereochemical purity.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-Pyridinecarboxamide,n-[(2R)-1,2,3,4-Tetrahydro-2-Naphthalenyl]-(9Ci)
CAS No.	449181-60-6
Molecular Formula	C₁₆H₁₈N₂O
Molecular Weight	254.33 g/mol
Synonyms	N-[(2R)-1,2,3,4-Tetrahydro-2-naphthalenyl]-4-pyridinecarboxamide; (R)-N-(1,2,3,4-Tetrahydronaphthalen-2-yl)isonicotinamide; (R)-N-(1,2,3,4-Tetrahydronaphthalen-2-yl)pyridine-4-carboxamide; 4-Pyridinecarboxamide, N-[(2R)-1,2,3,4-tetrahydro-2-naphthalenyl]- (9CI); (R)-Tetrahydronaphthalen-2-yl isonicotinamide; Isonicotinamide, N-[(2R)-1,2,3,4-tetrahydro-2-naphthalenyl]-; A chiral tetralin-isonicotinamide derivative
EINECS	Contact for details

Quality Control

Our production of 4-Pyridinecarboxamide,n-[(2R)-1,2,3,4-Tetrahydro-2-Naphthalenyl]-(9Ci) adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure consistent identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with client specifications and relevant industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.