Description

[1-(3-Chloro-4-Fluorobenzoyl)-4-Fluoropiperidin-4-Yl]Hydroxyacetonitrile (Wxg02787) is a high-purity, advanced pharmaceutical intermediate characterized by its unique fluorinated piperidine and benzoyl-substituted acetonitrile structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, including potential candidates for central nervous system (CNS) and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, especially those targeting specific biological receptors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• API Development: Serves as a critical precursor in the production route for Active Pharmaceutical Ingredients, particularly in fluorinated compound series.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Biochemical Tool Compound: Potential use in biochemical assays and as a probe for studying enzyme inhibition or receptor binding mechanisms.

Basic Information

Product Name	[1-(3-Chloro-4-Fluorobenzoyl)-4-Fluoropiperidin-4-Yl]Hydroxyacetonitrile (Wxg02787)
CAS No.	448920-98-7
Molecular Formula	C14H13ClF2N2O2
Molecular Weight	314.72 g/mol
Synonyms	Wxg02787; 2-Hydroxy-2-[4-fluoro-1-(3-chloro-4-fluorobenzoyl)piperidin-4-yl]acetonitrile; 4-Fluoro-1-(3-chloro-4-fluorobenzoyl)-4-piperidineacetonitrile, α-hydroxy-; (4-Fluoro-1-{[3-chloro-4-fluorophenyl]carbonyl}-4-piperidinyl)hydroxyacetonitrile; 1-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-(hydroxyacetonitrile)piperidine; Hydroxy(4-fluoro-1-{[3-chloro-4-fluorophenyl]carbonyl}-4-piperidinyl)acetonitrile
EINECS	Contact for details

Quality Control

Our [1-(3-Chloro-4-Fluorobenzoyl)-4-Fluoropiperidin-4-Yl]Hydroxyacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its chemical nature, it should be kept separate from strong bases and fluorides. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.