Description

6-(3-Chloro-4-Fluorobenzoyl)-1-Oxa-6-Azaspiro[2.5]Octane-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and heterocyclic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-infective therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic scaffold, which can impart favorable metabolic stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Serves as a critical starting material or intermediate for contract research organizations (CROs) and CDMOs producing bespoke compounds for clients.
• API Synthesis: Incorporated into the synthetic pathway of complex target molecules during process development and scale-up activities.
• Chemical Biology Probes: Potential use in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	6-(3-Chloro-4-Fluorobenzoyl)-1-Oxa-6-Azaspiro[2.5]Octane-2-Carbonitrile
CAS No.	448920-97-6
Molecular Formula	C15H12ClFN2O2
Molecular Weight	306.72 g/mol
Synonyms	1-Oxa-6-azaspiro[2.5]octane-2-carbonitrile, 6-[(3-chloro-4-fluorophenyl)carbonyl]-; 6-(3-Chloro-4-fluorobenzoyl)-1-oxa-6-azaspiro[2.5]octane-2-carbonitrile; 448920-97-6; 6-(3-Chloro-4-fluorobenzoyl)-1-oxa-6-azaspiro[2,5]octane-2-carbonitrile; Spiro[oxirane-2,2'-1-oxa-6-azaspiro[2.5]octane]-6'-carboxamide Derivative; AKOS025311324; A-OMEGA BLD SC-00419
EINECS	Contact for details

Quality Control

Our 6-(3-Chloro-4-Fluorobenzoyl)-1-Oxa-6-Azaspiro[2.5]Octane-2-Carbonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.