Description

4-Chloro-6-(Hydroxymethyl)Picolinonitrile is a versatile and high-value heterocyclic building block in organic synthesis. This compound matters for its bifunctional reactivity, featuring both a chloro-substituent and a hydroxymethyl group on a pyridine core, enabling diverse chemical transformations. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, such as active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides due to its pyridine-based structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CMOs for client-specific research and scale-up projects.
• Academic Research: Utilized in universities and research institutes for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	4-Chloro-6-(Hydroxymethyl)Picolinonitrile
CAS No.	448907-47-9
Molecular Formula	C7H5ClN2O
Molecular Weight	168.58 g/mol
Synonyms	4-Chloro-6-(hydroxymethyl)pyridine-2-carbonitrile; 2-Cyano-4-chloro-6-(hydroxymethyl)pyridine; 4-Chloro-6-(hydroxymethyl)-2-pyridinecarbonitrile; 6-(Hydroxymethyl)-4-chloropicolinonitrile; 4-Chloro-6-hydroxymethylpicolinonitrile; Picolinonitrile, 4-chloro-6-(hydroxymethyl)-; (4-Chloro-6-pyridinyl)methanol, 2-cyano-
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(Hydroxymethyl)Picolinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.