Description

3H-Oxazolo[3,4-A]Pyridin-3-One, 1,5,8,8A-Tetrahydro-8-Hydroxy-, (8S,8As)- (9Ci) is a high-purity, stereochemically defined heterocyclic compound of significant interest in advanced organic synthesis. This specialized intermediate is valued for its unique fused oxazolo-pyridinone scaffold, which serves as a critical building block for the development of novel pharmacologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective targets.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the optimization and pilot-scale synthesis of candidate drugs.
• Academic & Institutional Research: Employed in universities and research institutes for studying heterocyclic chemistry, asymmetric synthesis, and novel reaction methodologies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry in custom synthesis and development projects.
• Chemical Biology Probes: Potential use in the design and synthesis of molecular probes for investigating biological pathways and target validation.

Basic Information

Product Name	3H-Oxazolo[3,4-A]Pyridin-3-One, 1,5,8,8A-Tetrahydro-8-Hydroxy-, (8S,8As)- (9Ci)
CAS No.	448896-89-7
Molecular Formula	C7H9NO3
Molecular Weight	155.15 g/mol
Synonyms	(8S,8aR)-1,5,8,8a-Tetrahydro-8-hydroxy-3H-oxazolo[3,4-a]pyridin-3-one; (8S,8aR)-8-Hydroxy-1,5,8,8a-tetrahydro-3H-oxazolo[3,4-a]pyridin-3-one; 8-Hydroxy-1,5,8,8a-tetrahydro-3H-oxazolo[3,4-a]pyridin-3-one, (8S,8aR)-; Oxazolo[3,4-a]pyridin-3-one, 1,5,8,8a-tetrahydro-8-hydroxy-, (8S,8aR)-; CAS 448896-89-7
EINECS	Contact for details

Quality Control

Our 3H-Oxazolo[3,4-A]Pyridin-3-One, 1,5,8,8A-Tetrahydro-8-Hydroxy-, (8S,8As)- (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.