Description

2-((1-(4-Acetoxyphenyl)-2,5-Dioxopyrrolidin-3-Yl)Thio)Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific enzymatic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents. The product is supplied with full traceability and meets stringent quality standards required for cGMP applications.

Application

• Pharmaceutical Intermediate: A key precursor in the research and synthesis of novel drug candidates, especially in oncology and anti-inflammatory therapeutic areas.
• Biochemical Research: Used as a reference standard or a reagent in enzymatic studies and proteomics research due to its specific molecular scaffold.
• Organic Synthesis Building Block: Employed in complex multi-step organic syntheses to construct fused heterocyclic systems for material science or medicinal chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-((1-(4-Acetoxyphenyl)-2,5-Dioxopyrrolidin-3-Yl)Thio)Nicotinic Acid
CAS No.	448198-57-0
Molecular Formula	C18H14N2O6S
Molecular Weight	386.38 g/mol
Synonyms	2-[(1-(4-Acetyloxyphenyl)-2,5-dioxo-3-pyrrolidinyl)thio]pyridine-3-carboxylic acid; 2-((1-(4-Acetoxyphenyl)-2,5-dioxo-3-pyrrolidinyl)thio)nicotinic acid; 3-Pyridinecarboxylic acid, 2-[[1-[4-(acetyloxy)phenyl]-2,5-dioxo-3-pyrrolidinyl]thio]-; 448198-57-0; Nicotinic acid, 2-((1-(4-acetoxyphenyl)-2,5-dioxopyrrolidin-3-yl)thio)-
EINECS	Contact for details

Quality Control

Our 2-((1-(4-Acetoxyphenyl)-2,5-Dioxopyrrolidin-3-Yl)Thio)Nicotinic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.