Description

1-(4-Fluorophenyl)-3-Methyl-4-[3-(Trifluoromethyl)Phenyl]-1H-Pyrazol-5-Amine is a high-purity, multi-functional pyrazole derivative of significant interest in advanced chemical synthesis. This compound matters for its role as a critical pharmaceutical intermediate and a versatile building block in the development of novel active ingredients. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries seeking to incorporate its unique trifluoromethyl and fluorophenyl motifs into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functional additive in the research of advanced polymers and organic electronic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for designing enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API development.

Basic Information

Product Name	1-(4-Fluorophenyl)-3-Methyl-4-[3-(Trifluoromethyl)Phenyl]-1H-Pyrazol-5-Amine
CAS No.	446275-99-6
Molecular Formula	C17H13F4N3
Molecular Weight	335.30 g/mol
Synonyms	4-(3-(Trifluoromethyl)phenyl)-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amine; 1H-Pyrazol-5-amine, 1-(4-fluorophenyl)-3-methyl-4-[3-(trifluoromethyl)phenyl]-; 446275-99-6; 5-Amino-1-(4-fluorophenyl)-3-methyl-4-(3-(trifluoromethyl)phenyl)pyrazole; 4-[3-(Trifluoromethyl)phenyl]-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amine
EINECS	Contact for details

Quality Control

Our production of 1-(4-Fluorophenyl)-3-Methyl-4-[3-(Trifluoromethyl)Phenyl]-1H-Pyrazol-5-Amine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications using advanced analytical techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.