Description

Repertaxin L-Lysine Salt is a high-purity, non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2. This compound is a critical research-grade chemical for investigating inflammatory pathways and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on immunology, oncology, and inflammatory disease models.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-inflammatory and anti-cancer drugs targeting the CXCR1/2 pathway.
• Biochemical Assay Development: Used as a selective inhibitor in in vitro cell-based assays (e.g., chemotaxis, calcium flux) to study neutrophil migration and activation mechanisms.
• Preclinical Studies: Employed in animal models of diseases such as arthritis, psoriasis, chronic obstructive pulmonary disease (COPD), and certain cancers to validate therapeutic targets.
• Mechanism of Action (MoA) Studies: Essential for elucidating the role of IL-8 (CXCL8) and its receptors in various inflammatory and autoimmune conditions.
• High-Throughput Screening (HTS): Acts as a control compound in screening campaigns to identify new modulators of the CXCR1 and CXCR2 receptors.

Basic Information

Product Name	Repertaxin L-Lysine Salt
CAS No.	446024-42-6
Molecular Formula	C₂₉H₃₈N₄O₇ • C₆H₁₄N₂O₂
Molecular Weight	658.75 g/mol
Synonyms	Repertaxin Lysine Salt; (R)-N-(3-(Aminomethyl)phenyl)-N-(1H-indazol-5-yl)urea L-Lysine Salt; 1H-Indazole-5-urea, N-(3-(aminomethyl)phenyl)-N-(5-fluoro-2-methylphenyl)-, (R)-, monohydrochloride (salt with L-lysine); CXCR1/2 Inhibitor, Repertaxin; DF 2156A (Lysine Salt); DF-2156A; Reparixin Lysine Salt
EINECS	Contact for details

Quality Control

Our Repertaxin L-Lysine Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets the stringent requirements for research and development use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.