Description

1-[(tert-Butoxy)Carbonyl]-3,4-Dihydro-1,8-Naphthyridine-7(2H)-Acetic Acid is a sophisticated naphthyridine derivative, a key building block in modern pharmaceutical synthesis. Its value lies in its role as a protected intermediate, enabling the precise construction of complex molecules with high selectivity and yield. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel small-molecule therapeutics, enzyme inhibitors, and other bioactive compounds. Its controlled reactivity makes it a cornerstone for advancing medicinal chemistry projects.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved potency and pharmacokinetic profiles.
• Protease Inhibitor Synthesis: Serves as a precursor in the construction of molecules designed to inhibit specific proteases, which are important targets in virology and cancer research.
• Chemical Biology Probes: Utilized to create labeled or tagged compounds for studying biological pathways and target engagement within cells.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and niche APIs.
• Academic Research: Employed in university and institutional labs for fundamental research in heterocyclic chemistry and new synthetic methodology development.

Basic Information

Product Name	1-[(tert-Butoxy)Carbonyl]-3,4-Dihydro-1,8-Naphthyridine-7(2H)-Acetic Acid
CAS No.	445492-19-3
Molecular Formula	C16H20N2O4
Molecular Weight	304.34 g/mol
Synonyms	Boc-1,8-Naphthyridine-7-acetic Acid Derivative; 7-(Carboxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxylic Acid tert-Butyl Ester; 1-Boc-1,2,3,4-tetrahydro-1,8-naphthyridine-7-acetic Acid; tert-Butyl 7-(carboxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate; 1,8-Naphthyridine-7-acetic Acid, 1,2,3,4-tetrahydro-1-[(1,1-dimethylethoxy)carbonyl]-; 445492-19-3; Boc-DHN-7-CH2COOH
EINECS	Contact for details

Quality Control

Every batch of 1-[(tert-Butoxy)Carbonyl]-3,4-Dihydro-1,8-Naphthyridine-7(2H)-Acetic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent batch-to-batch quality suitable for sensitive pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.