Description

(3,5-Difluorophenylethynyl)trimethylsilane is a high-purity organosilicon intermediate featuring a difluorophenylacetylene moiety. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in cross-coupling reactions. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the difluorophenyl group can improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to create conjugated systems and extended π-networks.
• Organic Light-Emitting Diodes (OLEDs): Employed in the research and development of fluorinated organic semiconductors and emissive layer materials.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new fluorinated compounds and silicon-protected acetylene chemistry.

Basic Information

Product Name	(3,5-Difluorophenylethynyl)trimethylsilane
CAS No.	445491-09-8
Molecular Formula	C11H12F2Si
Molecular Weight	210.30 g/mol
Synonyms	Trimethyl((3,5-difluorophenyl)ethynyl)silane; 1-((3,5-Difluorophenyl)ethynyl)-1,1,1-trimethylsilane; 3,5-Difluorophenylacetylene trimethylsilyl ether; TMS-3,5-difluorophenylacetylene; (3,5-Difluorophenyl)ethynyltrimethylsilane; Silane, trimethyl[(3,5-difluorophenyl)ethynyl]-; 3,5-Difluoro(phenylethynyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our (3,5-Difluorophenylethynyl)trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.