Description

2-Bromo-6-Ethynylpyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromo substituent and an ethynyl group, makes it an invaluable intermediate for constructing complex molecular architectures through cross-coupling and click chemistry reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides by introducing the ethynylpyridine moiety into lead structures.
• Material Science: Building block for metal-organic frameworks (MOFs), conductive polymers, and liquid crystals due to its rigid, linear ethynyl group.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions to form biaryl and other conjugated systems.
• Click Chemistry: The terminal alkyne group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and polymer functionalization.
• Ligand Synthesis: Used to prepare novel nitrogen-containing ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Bromo-6-Ethynylpyridine
CAS No.	445468-63-3
Molecular Formula	C7H4BrN
Molecular Weight	182.02 g/mol
Synonyms	6-Ethynyl-2-bromopyridine; 2-Bromo-6-ethynylpyridine; 2-Bromo-6-ethynyl-pyridine; Pyridine, 2-bromo-6-ethynyl-; (6-Bromopyridin-2-yl)acetylene
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Ethynylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.