Description

(E)-6-((tert-Butyldiphenylsilyl)Oxy)-3-Methylhex-2-En-1-Ol CAS NO 445424-76-0 is a high-purity, protected alcohol intermediate featuring a tert-butyldiphenylsilyl (TBDPS) ether group. This compound is valued for its role as a key synthetic building block in complex organic synthesis, where the TBDPS group provides robust protection for the hydroxyl functionality under a wide range of reaction conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the production of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for steroids, prostaglandins, and other complex therapeutic molecules.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where its protected alcohol functionality allows for selective chemical transformations.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require precise stereochemistry and functional group manipulation.
• Academic & Industrial R&D: A valuable reagent in organic chemistry laboratories for methodology development and the construction of complex natural product analogs.
• Material Science Precursor: Acts as a monomer or modifying agent in the synthesis of specialized polymers and advanced organic materials with tailored properties.

Basic Information

Product Name	(E)-6-((tert-Butyldiphenylsilyl)Oxy)-3-Methylhex-2-En-1-Ol
CAS No.	445424-76-0
Molecular Formula	C23H32O2Si
Molecular Weight	368.59 g/mol
Synonyms	(E)-6-[(tert-Butyldiphenylsilyl)oxy]-3-methyl-2-hexen-1-ol; 3-Methyl-6-[(1,1-dimethylethyl)diphenylsilyl]oxy-2-hexen-1-ol, (E)-; TBDPS-protected 3-Methyl-2-hexen-1,6-diol; (E)-6-(tert-Butyldiphenylsiloxy)-3-methylhex-2-en-1-ol; (2E)-6-[(tert-Butyldiphenylsilyl)oxy]-3-methyl-2-hexen-1-ol; tert-Butyl((E)-5-(hydroxymethyl)-2-methylpent-2-en-1-yl)oxy)diphenylsilane
EINECS	Contact for details

Quality Control

Our (E)-6-((tert-Butyldiphenylsilyl)Oxy)-3-Methylhex-2-En-1-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS to confirm identity, isomeric purity, and chemical composition. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (GC/HPLC)	≥ 95.0% (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.