Description

6-(Difluoromethyl)-2-[(5-Formyl-2-Methoxybenzyl)Thio]-4-Phenylnicotinonitrile is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. Its complex molecular architecture, featuring a difluoromethyl group, a formyl moiety, and a nitrile functionality, makes it a critical intermediate for constructing novel compounds with targeted properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing next-generation active ingredients, particularly those requiring fluorinated scaffolds for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Acts as a building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the development of chemical tools for studying biological systems.
• Fluorine Chemistry: A valuable substrate for further fluorination reactions and the study of structure-activity relationships (SAR) in medicinal chemistry.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and fine chemical manufacturers engaged in bespoke synthesis projects.

Basic Information

Product Name	6-(Difluoromethyl)-2-[(5-Formyl-2-Methoxybenzyl)Thio]-4-Phenylnicotinonitrile
CAS No.	445260-24-2
Molecular Formula	C22H16F2N2O2S
Molecular Weight	410.44 g/mol
Synonyms	4-Phenyl-6-(difluoromethyl)-2-[[(5-formyl-2-methoxyphenyl)methyl]thio]-3-pyridinecarbonitrile; 2-[[(5-Formyl-2-methoxyphenyl)methyl]thio]-6-(difluoromethyl)-4-phenyl-3-pyridinecarbonitrile; 6-(Difluoromethyl)-2-[(5-formyl-2-methoxybenzyl)sulfanyl]-4-phenylpyridine-3-carbonitrile; Nicotinonitrile, 6-(difluoromethyl)-2-[(5-formyl-2-methoxybenzyl)thio]-4-phenyl-; 445260-24-2
EINECS	Contact for details

Quality Control

Our production of 6-(Difluoromethyl)-2-[(5-Formyl-2-Methoxybenzyl)Thio]-4-Phenylnicotinonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to validate specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.