Description

n-Adamantan-1-Yl-2-Chloro-Nicotinamide is a specialized organic compound featuring a unique adamantane-nicotinamide hybrid structure. This molecular architecture makes it a valuable pharmaceutical intermediate and research chemical for developing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams seeking to incorporate rigid, lipophilic adamantyl groups into target compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used to study structure-activity relationships (SAR) by introducing the adamantane moiety to modulate pharmacokinetic properties like lipophilicity and metabolic stability.
• Organic Synthesis Reference Standard: Serves as a pure standard for analytical method development and validation in QC laboratories.
• Chemical Biology Probes: Potential precursor for developing enzyme inhibitors or receptor ligands due to its specific molecular recognition features.
• Advanced Material Synthesis: May be investigated as a monomer or additive for creating specialty polymers with enhanced thermal or mechanical properties.

Basic Information

Product Name	n-Adamantan-1-Yl-2-Chloro-Nicotinamide
CAS No.	445017-10-7
Molecular Formula	C₁₆H₁₇ClN₂O
Molecular Weight	288.77 g/mol
Synonyms	2-Chloro-N-(tricyclo[3.3.1.1³,⁷]dec-1-yl)nicotinamide; 1-Adamantyl 2-chloronicotinamide; N-(Adamantan-1-yl)-2-chloronicotinamide; 2-Chloro-N-(1-adamantyl)nicotinamide; Adamant-1-yl 2-chloropyridine-3-carboxylate; 445017-10-7; 2-Chloronicotinic acid adamantan-1-ylamide
EINECS	Contact for details

Quality Control

Our n-Adamantan-1-Yl-2-Chloro-Nicotinamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.