Description

Methyl 4-(Difluoromethyl)Benzoate is a high-purity fluorinated aromatic ester building block. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. It is essential for researchers and manufacturers in the fine chemical, pharmaceutical, and crop protection industries seeking to introduce difluoromethyl groups into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, where the difluoromethyl moiety can enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the development of fluorinated organic semiconductors and charge-transport materials.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to build biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated compounds.

Basic Information

Product Name	Methyl 4-(Difluoromethyl)Benzoate
CAS No.	444915-76-8
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	4-(Difluoromethyl)benzoic acid methyl ester; Methyl p-(difluoromethyl)benzoate; Benzoic acid, 4-(difluoromethyl)-, methyl ester; Methyl 4-difluoromethylbenzoate; p-(Difluoromethyl)benzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 4-(Difluoromethyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.