Description

Apratoxin B is a potent cytotoxic cyclic depsipeptide of marine origin, known for its unique chemical structure and significant biological activity. This compound is a valuable tool for researchers investigating novel mechanisms of action in oncology and cell biology, particularly in the study of protein translocation and secretory pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on cancer research and drug discovery.

Application

• Biomedical Research: Used as a potent chemical probe to study Sec61-mediated protein translocation and endoplasmic reticulum (ER) stress pathways.
• Oncology Research: Investigated for its cytotoxic properties against various cancer cell lines, aiding in the discovery of novel anti-cancer mechanisms.
• Chemical Biology: Serves as a reference standard and lead compound in structure-activity relationship (SAR) studies for marine natural products.
• Pharmacology Studies: Employed in preclinical research to understand the inhibition of cellular secretory processes and angiogenesis.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental studies in cell signaling and apoptosis.

Basic Information

Product Name	Apratoxin B
CAS No.	444885-29-4
Molecular Formula	C₄₅H₆₇N₅O₈S
Molecular Weight	838.11 g/mol
Synonyms	Apratoxin B; (3S,6S,9S,12S,18S,21S,24S,30S,33S)-30-[(2S)-Butan-2-yl]-21-(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaazatricyclo[30.3.0.0¹⁵,¹⁹]pentatriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; Cyclic depsipeptide Apratoxin B
EINECS	Contact for details

Quality Control

Our Apratoxin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research purposes. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.