Description

3-(4-(Aminomethyl)-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione Hydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant interest. This compound matters for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in targeted cancer therapies and immunomodulatory drugs. Pharmaceutical manufacturers, biotechnology research firms, and advanced academic laboratories require this material for process development and new drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of proprietary small-molecule drugs and novel chemical entities (NCEs).
• Oncology Research: Used in the development of targeted cancer therapeutics, including proteolysis-targeting chimeras (PROTACs) and immunomodulatory imide drugs (IMiDs).
• Chemical Biology & Proteomics: Serves as a molecular scaffold or linker for designing chemical probes to study protein-protein interactions and protein degradation pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API production.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	3-(4-(Aminomethyl)-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione Hydrochloride
CAS No.	444289-05-8
Molecular Formula	C14H16N3O3 • HCl
Molecular Weight	311.76 g/mol (Free base: 274.30 g/mol)
Synonyms	2,6-Dioxo-3-(4-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine hydrochloride; 3-(4-(Aminomethyl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione hydrochloride; 2-(2,6-Dioxopiperidin-3-yl)-4-(aminomethyl)isoindoline-1,3-dione hydrochloride; Aminomethyl-lenalidomide hydrochloride; (S)-3-(4-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride; CC-4047 derivative hydrochloride; Pomalidomide precursor analog hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(4-(Aminomethyl)-1-Oxoisoindolin-2-Yl)Piperidine-2,6-Dione Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral purity determination, and residual solvent analysis, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.