Description

Pruvanserin Hydrochloride is a high-purity, non-peptide small molecule compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its potent and selective antagonistic activity at specific serotonin receptor subtypes, making it a critical intermediate for investigating novel therapeutic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on central nervous system (CNS) drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting serotonin receptors.
• Neurological Research: Used as a reference standard and tool compound in preclinical studies to investigate the role of specific 5-HT receptor subtypes in CNS function and disorders.
• Drug Discovery Programs: Employed in high-throughput screening (HTS) and medicinal chemistry campaigns to develop new candidates for psychiatric and neurological conditions.
• Biochemical Assay Development: Utilized in the development and validation of in vitro binding and functional assays for receptor pharmacology studies.
• Academic Research: Supports university and institutional research into serotonin signaling pathways and their modulation.
• GMP Manufacturing: Suitable as a starting material or intermediate in the cGMP-compliant production of investigational new drugs (INDs).

Basic Information

Product Name	Pruvanserin Hydrochloride
CAS No.	443144-27-2
Molecular Formula	C22H25FN4O2 • HCl
Molecular Weight	432.92 g/mol
Synonyms	Pruvanserin HCl; Pruvanserin hydrochloride; 1-[2-[4-(5-Fluoro-1H-indol-3-yl)piperidin-1-yl]ethyl]-3,4-dihydro-2H-quinolin-2-one hydrochloride; EMDRL-934788 hydrochloride; 5-HT2A receptor antagonist; 5-HT2A antagonist
EINECS	Contact for details

Quality Control

Our Pruvanserin Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to relevant industry guidelines to support our clients' quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.