Description

1(2H)-Azulenone, 3,6,7,8-Tetrahydro-8-Hydroxy-3,8-Dimethyl-5-(1-Methylethyl)-, (3R,8R)- is a high-purity, stereochemically defined azulenone derivative. This compound serves as a critical chiral intermediate and building block for advanced organic synthesis, enabling the development of novel molecular architectures. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex stereochemistry.
• Medicinal Chemistry Research: Used as a core scaffold or precursor in the synthesis of novel drug candidates for biological screening and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of specialty chemicals, fragrances, and advanced organic materials where its unique azulenone structure imparts specific properties.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological development in organic synthesis, including catalysis and asymmetric synthesis projects.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method validation in laboratories.

Basic Information

Product Name	1(2H)-Azulenone, 3,6,7,8-Tetrahydro-8-Hydroxy-3,8-Dimethyl-5-(1-Methylethyl)-, (3R,8R)-
CAS No.	443128-64-1
Molecular Formula	C15H22O2
Molecular Weight	234.33 g/mol
Synonyms	(3R,8R)-8-Hydroxy-3,8-dimethyl-5-(propan-2-yl)-3,4,6,7-tetrahydroazulen-1(2H)-one; (3R,8R)-3,6,7,8-Tetrahydro-8-hydroxy-3,8-dimethyl-5-(1-methylethyl)-1(2H)-azulenone; (-)-Nootkatone epoxide derivative; Chiral Azulenone Derivative; (3R,8R)-Isomer of Tetrahydroazulenone
EINECS	Contact for details

Quality Control

Our 1(2H)-Azulenone derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (3R,8R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.