Description

Cy5.5-Se CAS NO 442912-55-2 is a selenium-containing cyanine dye derivative, a key functionalized intermediate for advanced bioconjugation. This compound is engineered to provide a reactive handle for labeling biomolecules, enabling the creation of highly sensitive near-infrared (NIR) probes. It is essential for researchers and manufacturers in the fields of biomedical imaging, diagnostics, and pharmaceutical development who require precise and stable fluorescent tags for in vivo and in vitro applications.

Application

• Bioconjugation Reagent: Primary use as a reactive intermediate for covalently attaching the Cy5.5 fluorophore to antibodies, peptides, proteins, and oligonucleotides.
• Near-Infrared Fluorescence Imaging (NIRF): Synthesis of targeted imaging probes for preclinical research in oncology, inflammation, and cardiovascular disease.
• Diagnostic Assay Development: Creation of fluorescent labels for ELISA, lateral flow assays, and other immunoassay platforms requiring high sensitivity in the NIR spectrum.
• Drug Delivery & Theranostics: Fabrication of multifunctional agents that combine therapeutic and imaging capabilities for real-time treatment monitoring.
• Flow Cytometry & Microscopy: Labeling of cellular targets for deep-tissue and high-resolution imaging applications where minimal autofluorescence is critical.
• Material Science: Functionalization of nanoparticles and polymers to create smart materials with optical reporting properties.

Basic Information

Product Name	Cy5.5-Se
CAS No.	442912-55-2
Molecular Formula	C44H51N2O3Se+
Molecular Weight	743.86 g/mol (for cation)
Synonyms	Cy5.5 Selenocyanate; Cy5.5-SeCN; Selenocyanato Cy5.5; 2-((1E,3E)-5-((E)-2-((1E,3E)-3-(3-((E)-2-((E)-3,3-Dimethyl-5-sulfo-1-(4-sulfobutyl)indolin-2-ylidene)ethylidene)-2-((E)-1-(4-sulfobutyl)-3,3-dimethylindolin-2-ylidene)cyclopent-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfobutyl)indol-1-ium-5-yl)vinyl)-3,3-dimethyl-1-(4-sulfobutyl)-3H-indol-1-ium Selenocyanate; Sulfo-Cyanine5.5 Selenocyanate; Near-IR Dye SeCN
EINECS	Contact for details

Quality Control

Our Cy5.5-Se is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and spectrophotometry for optical property validation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant (e.g., in a sealed bag with silica gel) due to its hygroscopic nature. For long-term stability, store under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Dark green to blue solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Absorption (λmax)	~680 - 690 nm
Emission (λmax)	~710 - 720 nm
Extinction Coefficient (ε)	≥ 190,000 cm⁻¹M⁻¹
Water Content (KF)	< 5.0 %
Solubility	Soluble in DMSO, DMF, water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.