Description

(R)-1-Boc-Pyrrolidine-3-Carboxylic Acid Methyl Ester CAS NO 441717-40-4 is a high-purity chiral building block and protected amino acid derivative essential for modern pharmaceutical synthesis. This compound is a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and other therapeutic areas. It is primarily used by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in peptide synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid derivative for the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for constructing compound libraries and optimizing lead structures in R&D.
• Asymmetric Synthesis: Utilized in catalytic asymmetric reactions to introduce the (R)-configured pyrrolidine scaffold, a common motif in bioactive compounds.
• Protease Inhibitor Development: Acts as a core structural component in the design and synthesis of protease inhibitors.
• Chemical Biology Research: Employed in the synthesis of probes and labeled compounds for studying biological pathways and target engagement.

Basic Information

Product Name	(R)-1-Boc-Pyrrolidine-3-Carboxylic Acid Methyl Ester
CAS No.	441717-40-4
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxylic acid methyl ester; Methyl (R)-1-Boc-3-pyrrolidinecarboxylate; (R)-Methyl 1-Boc-pyrrolidine-3-carboxylate; (R)-1-N-Boc-3-Carbomethoxypyrrolidine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid methyl ester; (R)-1-Boc-3-pyrrolidine methyl carboxylate
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-Pyrrolidine-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided to guarantee reliable and consistent performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.