Description

(3Ar,7Ar)-Rel-5-Boc-Hexahydro-1-Oxo-Furo[3,4-C]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused furopyridine structure. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a protected amine group for selective chemical transformations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly those targeting the central nervous system.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Protease Inhibitor Synthesis: Potential building block for the development of inhibitors targeting specific enzymatic pathways.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and the synthesis of novel heterocyclic compounds.

Basic Information

Product Name	(3Ar,7Ar)-Rel-5-Boc-Hexahydro-1-Oxo-Furo[3,4-C]Pyridine
CAS No.	441297-78-5
Molecular Formula	C₁₆H₂₅NO₅
Molecular Weight	311.37 g/mol
Synonyms	5-(tert-Butoxycarbonyl)-rel-(3aR,7aR)-hexahydro-1-oxofuro[3,4-c]pyridine; tert-Butyl (3aR,7aR)-1-oxohexahydrofuro[3,4-c]pyridine-5(1H)-carboxylate; (3aR,7aR)-5-Boc-octahydro-1-oxofuro[3,4-c]pyridine; 5-Boc-1-oxo-hexahydro-furo[3,4-c]pyridine; rel-(3aR,7aR)-5-(tert-Butoxycarbonyl)hexahydro-1-oxofuro[3,4-c]pyridine; BOC-protected furopyridinone; Furo[3,4-c]pyridine-1(3H)-one, 5-[[(1,1-dimethylethoxy)carbonyl]hexahydro-, (3aR,7aR)-rel-
EINECS	Contact for details

Quality Control

Our (3Ar,7Ar)-Rel-5-Boc-Hexahydro-1-Oxo-Furo[3,4-C]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification tests. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.