Description

4-Hydroxy-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a sophisticated piperidine derivative and a key chiral building block in modern organic synthesis. This compound matters because it provides a protected, multifunctional scaffold essential for constructing complex molecules with high stereochemical control. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), novel drug candidates, and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetic Chemistry: Serves as a constrained amino acid analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce chiral centers into target molecules.
• Agrochemical Research: Employed in the synthesis of advanced intermediates for novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & Contract Research: Used in university laboratories and CROs (Contract Research Organizations) for methodological development and exploratory chemistry projects.

Basic Information

Product Name	4-Hydroxy-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	441044-12-8
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic Acid; 4-Hydroxy-2-piperidinecarboxylic Acid 1-(1,1-Dimethylethyl) Ester; 1-Boc-4-hydroxypipecolic Acid; 4-Hydroxy-1-N-Boc-pipecolic Acid; (2S,4R)-1-tert-Butyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate (stereoisomer); 4-Hydroxy-L-pipecolic Acid 1-tert-Butyl Ester; 4-Hydroxypipecolic Acid N-Boc Derivative
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-Piperidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.