Description

L-Proline, 4-Hydroxy-, Ethyl Ester, (4S)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative, specifically the ethyl ester of trans-4-hydroxy-L-proline. This compound is a critical chiral building block and intermediate in advanced organic synthesis, valued for its role in constructing complex molecular architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the development of peptide-based therapeutics and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, including protease inhibitors and other peptide mimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce the constrained 4-hydroxyproline scaffold, which can influence peptide conformation and stability.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway research related to collagen biosynthesis and post-translational modifications.
• Agrochemical Synthesis: An intermediate in the production of advanced, biologically active compounds for crop protection.
• Cosmetic Peptides: A potential building block for synthetic peptides used in anti-aging and skin-repair cosmetic formulations.

Basic Information

Product Name	L-Proline, 4-Hydroxy-, Ethyl Ester, (4S)- (9Ci)
CAS No.	440678-43-3
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	(2S,4S)-4-Hydroxypyrrolidine-2-carboxylic acid ethyl ester; Ethyl (4S)-4-hydroxy-L-prolinate; trans-4-Hydroxy-L-proline ethyl ester; HYP-OEt; 4-Hydroxy-L-proline ethyl ester; L-4-Hydroxyproline ethyl ester; (4S)-4-Hydroxy-L-proline ethyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-, Ethyl Ester, (4S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.