Description

4-((tert-Butyldiphenylsilyl)Oxy)-2,2-Dimethylbutan-1-Ol is a specialized organosilicon-protected alcohol intermediate of significant importance in advanced organic synthesis. Its primary value lies in its role as a robust protecting group for primary alcohols, offering superior stability under a wide range of reaction conditions compared to more common silyl ethers. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over multi-step synthetic sequences, particularly in the production of complex natural products and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Natural Product Synthesis: Used to protect hydroxyl groups during the intricate total synthesis of natural products with sensitive functional groups.
• Peptide and Oligosaccharide Chemistry: Provides selective protection for primary alcohols in the synthesis of complex biomolecules.
• Agrochemical Research: Serves as a precursor or protected intermediate in the development of novel pesticides and herbicides.
• Material Science: Potential monomer or modifying agent in the synthesis of specialized silicon-containing polymers and advanced materials.
• Asymmetric Synthesis: Employed in chiral synthesis where the stability of the protecting group is critical to maintain enantiomeric purity.

Basic Information

Product Name	4-((tert-Butyldiphenylsilyl)Oxy)-2,2-Dimethylbutan-1-Ol
CAS No.	439693-30-8
Molecular Formula	C22H32O2Si
Molecular Weight	356.58 g/mol
Synonyms	2,2-Dimethyl-4-[(2-methyl-1,1-diphenyl-1-silapropoxy)]-1-butanol; 1-Butanol, 4-[(1,1-dimethylethyl)diphenylsilyl]oxy]-2,2-dimethyl-; 4-(tert-Butyldiphenylsilyloxy)-2,2-dimethylbutan-1-ol; TBDPS-protected 2,2-dimethyl-1,4-butanediol; 4-(TBDPSO)-2,2-dimethyl-1-butanol; 2,2-Dimethyl-4-(tert-butyldiphenylsilyloxy)butan-1-ol
EINECS	Contact for details

Quality Control

Our 4-((tert-Butyldiphenylsilyl)Oxy)-2,2-Dimethylbutan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.