Description

6-(3,5-Difluorophenyl)Pyridin-3-Amine CAS NO 438585-63-8 is a high-purity, functionalized pyridine derivative featuring a difluorophenyl substituent, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific fluorinated aromatic motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where the difluorophenyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or charge-transport materials, due to its electron-deficient aromatic system.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Ligand Synthesis: Useful for preparing specialized ligands in catalysis, particularly for transition metal complexes used in cross-coupling reactions.
• Fluorinated Compound Library: A valuable component for constructing diverse screening libraries focused on fluorinated compounds in early-stage drug discovery.

Basic Information

Product Name	6-(3,5-Difluorophenyl)Pyridin-3-Amine
CAS No.	438585-63-8
Molecular Formula	C11H8F2N2
Molecular Weight	206.19 g/mol
Synonyms	3-Amino-6-(3,5-difluorophenyl)pyridine; 6-(3,5-Difluorophenyl)-3-pyridinamine; 5-Amino-2-(3,5-difluorophenyl)pyridine; 2-(3,5-Difluorophenyl)-5-aminopyridine; 3-Pyridinamine, 6-(3,5-difluorophenyl)-; 438585-63-8; 6-(3,5-Difluorophenyl)pyridin-3-ylamine
EINECS	Contact for details

Quality Control

Our 6-(3,5-Difluorophenyl)Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.