Description

6-Difluoromethyl-2-Mercapto-4-Methyl-Nicotinonitrile is a high-value, multi-functional heterocyclic building block featuring a difluoromethyl group and a reactive mercapto moiety. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique fluorine substitution pattern can significantly enhance biological activity and metabolic stability. It is primarily needed by R&D chemists and process development teams in the agrochemical and pharmaceutical industries for creating novel active ingredients and fine chemicals.

Application

• Agrochemical Intermediate: A key synthon for the development of next-generation fungicides, herbicides, and insecticides, leveraging the bioisosteric properties of the difluoromethyl group.
• Pharmaceutical Building Block: Used in medicinal chemistry for the synthesis of drug candidates, particularly in areas targeting enzymes and receptors where fluorine substitution is beneficial.
• Material Science Research: Serves as a precursor for specialized ligands or functional molecules in advanced material applications.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of client-specific, complex molecules requiring this precise fluorinated nicotinonitrile scaffold.

Basic Information

Product Name	6-Difluoromethyl-2-Mercapto-4-Methyl-Nicotinonitrile
CAS No.	438218-60-1
Molecular Formula	C8H6F2N2S
Molecular Weight	200.21 g/mol
Synonyms	4-Methyl-6-(difluoromethyl)-2-mercaptonicotinonitrile; 2-Mercapto-4-methyl-6-(difluoromethyl)nicotinonitrile; 6-(Difluoromethyl)-2-mercapto-4-methyl-3-pyridinecarbonitrile; 3-Cyano-6-(difluoromethyl)-4-methyl-2(1H)-pyridinethione; 438218-60-1; Nicotinonitrile, 6-(difluoromethyl)-2-mercapto-4-methyl-
EINECS	Contact for details

Quality Control

Our 6-Difluoromethyl-2-Mercapto-4-Methyl-Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store the material under an inert atmosphere for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.