Description

(S)-3,3-Dimethylbuty-2-Ylisocyanide is a chiral isocyanide building block of significant value in modern synthetic organic chemistry. Its importance lies in its role as a versatile precursor for the synthesis of complex, stereodefined heterocycles and bioactive molecules via multicomponent reactions. This high-purity intermediate is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drugs and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for constructing complex molecular scaffolds in drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel, stereoselective pesticides and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Multicomponent Reaction (MCR) Chemistry: Essential reactant in Passerini and Ugi-type reactions to create diverse compound libraries.
• Peptidomimetic Research: Employed in the synthesis of peptide analogs and conformationally constrained biomolecules.
• Material Science Research: Investigated as a building block for functional polymers and advanced organic materials.

Basic Information

Product Name	(S)-3,3-Dimethylbuty-2-Ylisocyanide
CAS No.	438186-75-5
Molecular Formula	C7H11N
Molecular Weight	109.17 g/mol
Synonyms	(S)-3,3-Dimethyl-1-isocyano-1-butene; (S)-3,3-Dimethylbut-1-en-1-yl isocyanide; (S)-1-Isocyano-3,3-dimethylbut-1-ene; (S)-t-Butyl isocyanoethene; (S)-2,2-Dimethyl-3-isocyanopropene; (S)-Isocyanomethylene-tert-butane; (S)-Isocyanide of 3,3-dimethylbutyraldehyde oxime
EINECS	Contact for details

Quality Control

Our (S)-3,3-Dimethylbuty-2-Ylisocyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.