Description

(R)-3,3-Dimethylbut-2-Ylisocyanide is a chiral isocyanide building block of significant interest in modern synthetic chemistry. This compound matters as a versatile reagent for the synthesis of complex, stereodefined molecules, particularly in the construction of heterocycles and as a ligand in asymmetric catalysis. Pharmaceutical, agrochemical, and advanced materials research and development teams need it for creating novel active ingredients and functional molecules with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Catalysis: Employed as a chiral ligand or precursor for catalysts used in enantioselective transformations.
• Multicomponent Reactions (MCRs): A crucial component in Passerini and Ugi-type reactions for the efficient, one-pot generation of diverse chemical libraries.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science: Serves as a building block for chiral polymers, metal-organic frameworks (MOFs), and other functional materials.
• Peptidomimetics & Bio-conjugation: Facilitates the creation of isocyanide-containing peptides and bioconjugates for chemical biology applications.

Basic Information

Product Name	(R)-3,3-Dimethylbut-2-Ylisocyanide
CAS No.	438186-74-4
Molecular Formula	C7H11N
Molecular Weight	109.17 g/mol
Synonyms	(R)-3,3-Dimethyl-2-isocyanobutane; (R)-tert-Butyl isocyanide; (R)-t-Butyl isocyanide; (R)-2-Isocyano-2-methylpropane; (R)-2-Methyl-2-isocyanopropane; (R)-TosMIC analog; (R)-Tert-butylisonitrile
EINECS	Contact for details

Quality Control

Our (R)-3,3-Dimethylbut-2-Ylisocyanide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and light-sensitive nature, store the product in a cool (15-25°C), dry, and well-ventilated place. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.