Description

4-(1,2,3,6-Tetrahydropyridin-4-yl)benzonitrile hydrochloride is a high-purity chemical intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic research laboratories engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Active Pharmaceutical Ingredient (API) Development: Incorporated into the synthesis pathway of candidate APIs for preclinical and clinical studies.
• Chemical Biology Probes: Serves as a starting material for creating molecular probes to study biological pathways and protein interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	4-(1,2,3,6-Tetrahydropyridin-4-yl)benzonitrile Hydrochloride
CAS No.	437998-31-7
Molecular Formula	C12H13N2•HCl
Molecular Weight	220.71 g/mol
Synonyms	4-(1,2,3,6-Tetrahydro-4-pyridinyl)benzonitrile hydrochloride; 4-(1,2,3,6-Tetrahydropyridin-4-yl)benzonitrile HCl; 4-Cyano-4'-(1,2,3,6-tetrahydropyridinyl)benzene hydrochloride; 1,2,3,6-Tetrahydro-4-(4-cyanophenyl)pyridine hydrochloride; 4-(4-Cyanophenyl)-1,2,3,6-tetrahydropyridine hydrochloride; 4-(1,2,3,6-Tetrahydropyridin-4-yl)phenyl cyanide hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(1,2,3,6-Tetrahydropyridin-4-yl)benzonitrile hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.