Description

5-Bromo-2-(trifluoromethyl)nicotinic acid is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the strategic combination of a bromine substituent and a trifluoromethyl group on the nicotinic acid scaffold, enabling precise molecular modifications and introducing desirable physicochemical properties. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing complex ligands used in catalysis and material science applications.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Advanced Material Research: Acts as a monomer or functionalization agent in the development of specialty polymers and organic electronic materials.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)nicotinic Acid
CAS No.	436799-36-9
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Bromo-6-(trifluoromethyl)pyridine-5-carboxylic acid; 5-Bromo-2-trifluoromethylnicotinic acid; 5-Bromo-2-(trifluoromethyl)-3-pyridinecarboxylic acid; 436799-36-9; Nicotinic acid, 5-bromo-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)nicotinic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.