Description

2-(Cyclohexylaminomethyl)Pyridine is a secondary amine derivative featuring a pyridine ring substituted with a cyclohexylaminomethyl group at the 2-position — a structurally distinctive ligand and synthetic intermediate widely employed in pharmaceutical and fine chemical development. Its molecular architecture confers high selectivity in metal coordination and reactivity in C–N bond-forming reactions, making it a critical building block for catalysts and bioactive molecules. This compound is essential for R&D laboratories and contract manufacturing organizations (CMOs) engaged in asymmetric synthesis, medicinal chemistry, and transition-metal-catalyzed cross-coupling processes. As 2-(Cyclohexylaminomethyl)Pyridine CAS NO 436099-92-2, it is globally recognized for consistent performance across scale-up and GMP-compliant production environments.

Application

• Chiral ligand in asymmetric allylic alkylation and hydroamination catalysis
• Key intermediate in the synthesis of selective kinase inhibitors and antiviral agents
• Building block for nitrogen-containing heterocyclic scaffolds in agrochemical discovery
• Ligand precursor for palladium and copper complexes used in C–N cross-coupling (e.g., Buchwald–Hartwig amination)
• Functional component in luminescent metal–organic frameworks (MOFs) for sensing applications
• Stabilizing agent for nanoparticle synthesis due to strong N-donor coordination affinity
• Reagent in the preparation of pH-responsive polymers and smart hydrogels
• Template molecule in supramolecular chemistry for host–guest system design

Basic Information

Product Name	2-(Cyclohexylaminomethyl)Pyridine
CAS No.	436099-92-2
Molecular Formula	C12H18N2
Molecular Weight	190.29 g/mol
Synonyms	2-[(Cyclohexylamino)methyl]pyridine; 2-(Cyclohexylaminomethyl)pyridine; CHAMP; Pyridine-2-ylmethylcyclohexylamine; 2-(Cyclohexylamino)methylpyridine; NSC 759512; 2-(Cyclohexylaminomethyl)pyridine hydrochloride (common salt form); 2-Pyridinemethanamine, N-cyclohexyl-
EINECS	604-325-0

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 2-(Cyclohexylaminomethyl)Pyridine is verified for identity, assay, residual solvents, heavy metals, and related substances using validated methods including HPLC, GC, IR, and NMR. Certificates of Analysis (COA) are available upon request and include full traceability to raw materials, manufacturing date, and expiry. The compound meets ACS Reagent Grade specifications and is manufactured under ISO 9001-certified quality management systems. For regulated applications, documentation supporting ICH Q5–Q7 compliance and REACH registration is provided on demand.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant storage or nitrogen-purged containers for long-term stability. Avoid contact with strong oxidizing agents and acidic vapors.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or viscous oil
Assay (by HPLC)	≥ 98.5%
Identification (IR)	Conforms to reference standard
Identification (NMR)	Conforms to reference standard
Loss on drying	≤ 0.5%
Residue on ignition	≤ 0.1%
Heavy metals (as Pb)	≤ 10 ppm
Related substances (by HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.