Description

1-Piperidin-4-Yl-Azepane is a structurally unique bicyclic amine featuring a piperidine ring fused at the 4-position to a seven-membered azepane moiety — a privileged scaffold in modern medicinal chemistry. It serves as a high-value building block for the synthesis of novel CNS-active compounds, kinase inhibitors, and GPCR-targeted therapeutics due to its enhanced conformational flexibility and improved pharmacokinetic profile over monocyclic analogues. Pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers rely on this intermediate for structure–activity relationship (SAR) studies and late-stage functionalization. The compound is commercially supplied as a high-purity reference standard and synthetic intermediate under the identifier 1-Piperidin-4-Yl-Azepane CAS NO 436099-86-4.

Application

• Key intermediate in the synthesis of selective serotonin receptor (5-HT6, 5-HT7) modulators for neurodegenerative disease research
• Building block for protease and tyrosine kinase inhibitor development in oncology drug discovery programs
• Chiral scaffold for asymmetric catalysis ligands in pharmaceutical process chemistry
• Core structure in PET radiotracer design for in vivo brain imaging studies
• Functionalized precursor for covalent PROTAC linker optimization
• Reference standard for LC-MS/MS method validation in bioanalytical laboratories
• Substrate in metal-catalyzed C–H amination reactions for library diversification
• Component in solid-phase peptide synthesis (SPPS) auxiliaries for constrained peptidomimetics

Basic Information

Product Name	1-Piperidin-4-Yl-Azepane
CAS No.	436099-86-4
Molecular Formula	C10H20N2
Molecular Weight	168.28 g/mol
Synonyms	1-(Piperidin-4-yl)azepane; 4-(Azepan-1-yl)piperidine; 1-[4-Piperidinyl]azepane; Azepane, 1-(4-piperidinyl)-; NSC 754893; UNII-7Z4VQ9X8LJ; AKOS025054529; Z1129892075; 1-(piperidin-4-yl)azepane hydrochloride (common salt form); 4-(1-Azepanyl)piperidine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 1-Piperidin-4-Yl-Azepane is verified for identity, assay, residual solvents, heavy metals, and related substances using validated methods including HPLC, GC, NMR, and IR spectroscopy. Certificates of Analysis (COA) are available upon request and conform to ICH Q2(R2) guidelines. All manufacturing and testing processes adhere to ISO 9001:2015 and follow cGMP principles where applicable for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant storage or nitrogen-purged packaging for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identity (IR)	Conforms to reference spectrum
Assay (by HPLC)	≥ 98.0%
Related Substances (HPLC)	≤ 1.5% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water (Karl Fischer)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.