Description

(R)-Benzyl 3-Formylpiperidine-1-Carboxylate is a high-value chiral building block and advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of complex bioactive molecules, particularly in medicinal chemistry where the (R)-enantiomer is often critical for specific biological activity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Serves as a versatile precursor for introducing the (R)-3-formylpiperidine moiety into more complex molecular architectures via further functionalization.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of candidate drugs.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	(R)-Benzyl 3-Formylpiperidine-1-Carboxylate
CAS No.	435275-28-8
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	1-Carbobenzyloxy-(R)-3-formylpiperidine; (R)-1-(Benzyloxycarbonyl)-3-formylpiperidine; (R)-1-CBz-3-formylpiperidine; (R)-N-Cbz-3-formylpiperidine; (R)-3-Formyl-1-N-(benzyloxycarbonyl)piperidine; Benzyl (3R)-3-formylpiperidine-1-carboxylate; (R)-1-Benzyloxycarbonyl-3-formylpiperidine; (R)-3-Formylpiperidine-1-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our (R)-Benzyl 3-Formylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles are available upon request. We support development with custom purity grades and specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.