Description

2-Triisopropylsilyl Oxazole is a high-value organosilicon-protected heterocyclic building block, essential for advanced synthetic chemistry. Its primary value lies in serving as a key, protected intermediate in the synthesis of complex pharmaceuticals and agrochemicals, enabling precise molecular construction. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: A crucial protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those containing oxazole or related heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require sophisticated heterocyclic architectures.
• Material Science Research: Serves as a precursor for developing functional organic materials, including organic semiconductors and liquid crystals.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Medicinal Chemistry: Employed in drug discovery programs for building diverse compound libraries and exploring structure-activity relationships (SAR).
• Peptide Mimetics: Used in the design and synthesis of peptidomimetics where the oxazole ring acts as a bioisostere.

Basic Information

Product Name	2-Triisopropylsilyl Oxazole
CAS No.	433332-27-5
Molecular Formula	C13H25NOSi
Molecular Weight	239.43 g/mol
Synonyms	2-[(Triisopropylsilyl)oxy]oxazole; Oxazole, 2-(triisopropylsilyl)-; 2-TIPS-oxazole; 2-Triisopropylsilyloxazole; TIPS-Oxazole; 2-(Triisopropylsilyl)oxazole; 2-Triisopropylsiloxyoxazole
EINECS	Contact for details

Quality Control

Every batch of 2-Triisopropylsilyl Oxazole is manufactured and tested under strict quality management protocols to ensure consistency and purity for critical R&D and scale-up applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.