Description

n-(6-Chloro-9H-Pyrido[3,4-B]Indol-8-Yl)-3-Pyridinecarboxamide Dihydrochloride is a high-purity, non-natural β-carboline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a versatile scaffold for the creation of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of targeted therapies and investigative pharmacological tools.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Tool Compound: Employed in in vitro and ex vivo studies to investigate enzyme interactions, receptor binding, and cellular signaling mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Preclinical Development: Utilized in the early-stage development of potential therapeutic agents for various disease states.

Basic Information

Product Name	n-(6-Chloro-9H-Pyrido[3,4-B]Indol-8-Yl)-3-Pyridinecarboxamide Dihydrochloride
CAS No.	431898-65-6
Molecular Formula	C₁₇H₁₂ClN₅O • 2HCl
Molecular Weight	407.68 g/mol (free base: 337.76 g/mol)
Synonyms	6-Chloro-8-[(pyridine-3-carbonyl)amino]-9H-pyrido[3,4-b]indole dihydrochloride; 431898-65-6; UNII-9G2C7S4T6F; 9H-Pyrido[3,4-b]indole-8-carboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridine-, dihydrochloride; 3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-, dihydrochloride; β-Carboline-8-carboxamide derivative dihydrochloride
EINECS	Contact for details

Quality Control

Our n-(6-Chloro-9H-Pyrido[3,4-B]Indol-8-Yl)-3-Pyridinecarboxamide Dihydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.