Description

3-Amino-n-(4-Chlorophenyl)-6,7-Dihydro-5H-Cyclopenta[B]Thieno[3,2-E]Pyridine-2-Carboxamide is a high-value, complex heterocyclic organic compound serving as a critical advanced intermediate in modern pharmaceutical research and development. Its intricate fused-ring structure, featuring cyclopenta, thieno, and pyridine moieties, makes it a versatile building block for synthesizing novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and fine chemical manufacturers engaged in the discovery and production of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Kinase Inhibitor Development: The structural motifs present are conducive to the development of potential kinase inhibitors, a major class of therapeutics for cancer and inflammatory diseases.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes to study enzyme function and cellular signaling mechanisms.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-Amino-n-(4-Chlorophenyl)-6,7-Dihydro-5H-Cyclopenta[B]Thieno[3,2-E]Pyridine-2-Carboxamide
CAS No.	428444-64-8
Molecular Formula	C17H14ClN3OS
Molecular Weight	343.83 g/mol
Synonyms	3-Amino-N-(4-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide; 3-Amino-N-(4-chlorophenyl)-5,6-dihydro-4H-cyclopenta[b]thieno[2,3-e]pyridine-2-carboxamide (alternative numbering); 428444-64-8; 3-Amino-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxylic acid (4-chlorophenyl)amide; 3-Amino-N-(p-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide; Cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide, 3-amino-N-(4-chlorophenyl)-6,7-dihydro-5H-
EINECS	Contact for details

Quality Control

Our production of 3-Amino-n-(4-Chlorophenyl)-6,7-Dihydro-5H-Cyclopenta[B]Thieno[3,2-E]Pyridine-2-Carboxamide adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.