Description

2-Fluoro-5-Iodo-3-Nitropyridine is a high-purity halogenated and nitrated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable scaffold for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and R&D professionals developing novel active ingredients, where its reactive sites enable precise functionalization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Stille couplings.
• Nucleophilic Aromatic Substitution: The fluorine and nitro groups activate the pyridine ring for selective displacement reactions, enabling diverse chemical transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	2-Fluoro-5-Iodo-3-Nitropyridine
CAS No.	426463-16-3
Molecular Formula	C5H2FIN2O2
Molecular Weight	267.98 g/mol
Synonyms	3-Nitro-2-fluoro-5-iodopyridine; 5-Iodo-2-fluoro-3-nitropyridine; 2-Fluoro-3-nitro-5-iodopyridine; Pyridine, 2-fluoro-5-iodo-3-nitro-; 426463-16-3; FC-6352; AI3-63520
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Iodo-3-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Solubility	Soluble in common organic solvents (DMSO, DMF, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.